Drug interactions
Digoxin + Penbutolol
Severity: Moderate
Digoxin and Penbutolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs slow AV nodal conduction, so combined use can cause additive bradycardia and heart block. This is relevant in older patients and those with conduction disease.
What this interaction means in plain words
Digoxin and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive negative chronotropic and dromotropic effects on the sinoatrial and AV nodes.
What to do
Monitor heart rate, ECG and PR interval, and adjust doses if symptomatic bradycardia or AV block develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Penbutolol?
MediHelp rates the interaction as moderate. Digoxin and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs slow AV nodal conduction, so combined use can cause additive bradycardia and heart block. This is relevant in older patients and those with conduction disease.
How serious is the interaction between Digoxin and Penbutolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and PR interval, and adjust doses if symptomatic bradycardia or AV block develops.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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