Drug interactions
Digoxin + Perindopril
Severity: Moderate
Digoxin and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may modestly raise serum digoxin concentrations in some patients, and renal function changes or electrolyte shifts with ACE inhibitors can further alter digoxin exposure. Digoxin toxicity could result in arrhythmia, nausea or visual disturbance.
What this interaction means in plain words
Digoxin and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Perindopril belongs to Cardiovascular.
Why it happens
Possible reduction in renal digoxin clearance; the mechanism is not firmly established.
What to do
Check serum digoxin concentration, renal function and potassium after starting or changing perindopril. Reduce the digoxin dose if levels are high or toxicity signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Perindopril?
MediHelp rates the interaction as moderate. Digoxin and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may modestly raise serum digoxin concentrations in some patients, and renal function changes or electrolyte shifts with ACE inhibitors can further alter digoxin exposure. Digoxin toxicity could result in arrhythmia, nausea or visual disturbance.
How serious is the interaction between Digoxin and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum digoxin concentration, renal function and potassium after starting or changing perindopril. Reduce the digoxin dose if levels are high or toxicity signs appear.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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