Drug interactions
Digoxin + Pindolol
Severity: Moderate
Digoxin and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pindolol and digoxin both slow AV conduction, so the combination can produce additive bradycardia or AV block. Although pindolol has intrinsic sympathomimetic activity, bradycardia can still occur.
What this interaction means in plain words
Digoxin and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive suppression of sinus and AV nodal conduction.
What to do
Monitor heart rate and ECG, particularly when starting or increasing doses, and reduce doses if symptomatic bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Pindolol?
MediHelp rates the interaction as moderate. Digoxin and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pindolol and digoxin both slow AV conduction, so the combination can produce additive bradycardia or AV block. Although pindolol has intrinsic sympathomimetic activity, bradycardia can still occur.
How serious is the interaction between Digoxin and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, particularly when starting or increasing doses, and reduce doses if symptomatic bradycardia occurs.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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