Drug interactions
Digoxin + Pleurisy root
Severity: Moderate
Digoxin and Pleurisy root: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pleurisy root (Asclepias tuberosa) is reported to contain cardiac glycoside-like compounds. Taken with digoxin it could add to the inotropic and conduction effects and raise the risk of digoxin-type toxicity such as arrhythmia, nausea and visual disturbance. The interaction is theoretical, but the narrow therapeutic index of digoxin makes it relevant.
What this interaction means in plain words
Digoxin and Pleurisy root can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect from cardenolide-type constituents acting on Na+/K+-ATPase.
What to do
Advise patients on digoxin to avoid pleurisy root products. If use cannot be avoided, monitor digoxin level, ECG and potassium and watch for signs of toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Pleurisy root?
MediHelp rates the interaction as moderate. Digoxin and Pleurisy root can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pleurisy root (Asclepias tuberosa) is reported to contain cardiac glycoside-like compounds. Taken with digoxin it could add to the inotropic and conduction effects and raise the risk of digoxin-type toxicity such as arrhythmia, nausea and visual disturbance. The interaction is theoretical, but the narrow therapeutic index of digoxin makes it relevant.
How serious is the interaction between Digoxin and Pleurisy root?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients on digoxin to avoid pleurisy root products. If use cannot be avoided, monitor digoxin level, ECG and potassium and watch for signs of toxicity.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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