Drug interactions
Digoxin + Procainamide
Severity: Moderate
Digoxin and Procainamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have narrow therapeutic windows and can affect cardiac conduction. Digoxin may modestly compete for renal tubular secretion with procainamide, and the combination can add to conduction slowing and arrhythmia risk, particularly in renal impairment.
What this interaction means in plain words
Digoxin and Procainamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion of cationic drugs plus additive effects on cardiac conduction.
What to do
Monitor ECG, serum procainamide/NAPA and digoxin levels, and renal function. Adjust doses accordingly, especially in elderly or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Procainamide?
MediHelp rates the interaction as moderate. Digoxin and Procainamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have narrow therapeutic windows and can affect cardiac conduction. Digoxin may modestly compete for renal tubular secretion with procainamide, and the combination can add to conduction slowing and arrhythmia risk, particularly in renal impairment.
How serious is the interaction between Digoxin and Procainamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, serum procainamide/NAPA and digoxin levels, and renal function. Adjust doses accordingly, especially in elderly or renally impaired patients.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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