Drug interactions
Digoxin + Propantheline
Severity: Moderate
Digoxin and Propantheline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propantheline slows gastrointestinal motility, which can lengthen the time digoxin tablets dissolve and are absorbed. This may raise digoxin levels, especially for slowly dissolving formulations.
What this interaction means in plain words
Digoxin and Propantheline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anticholinergic reduction in gut motility increases digoxin absorption time and extent.
What to do
Monitor serum digoxin and clinical signs of toxicity when starting or stopping propantheline. Reduce the digoxin dose if levels increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Propantheline?
MediHelp rates the interaction as moderate. Digoxin and Propantheline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propantheline slows gastrointestinal motility, which can lengthen the time digoxin tablets dissolve and are absorbed. This may raise digoxin levels, especially for slowly dissolving formulations.
How serious is the interaction between Digoxin and Propantheline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin and clinical signs of toxicity when starting or stopping propantheline. Reduce the digoxin dose if levels increase.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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