Drug interactions
Digoxin + Quercetin
Severity: Minor
Digoxin and Quercetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quercetin, a flavonoid supplement, may modulate intestinal P-glycoprotein and so alter digoxin absorption. Reported effects on digoxin exposure are inconsistent, and clinical significance is uncertain.
What this interaction means in plain words
Digoxin and Quercetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Quercetin may modulate P-glycoprotein efflux of digoxin, with variable effects on absorption.
What to do
Monitor digoxin serum concentration and clinical response if a quercetin supplement is started or stopped in a patient on digoxin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Quercetin?
MediHelp rates the interaction as minor. Digoxin and Quercetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quercetin, a flavonoid supplement, may modulate intestinal P-glycoprotein and so alter digoxin absorption. Reported effects on digoxin exposure are inconsistent, and clinical significance is uncertain.
How serious is the interaction between Digoxin and Quercetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin serum concentration and clinical response if a quercetin supplement is started or stopped in a patient on digoxin.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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