Drug interactions
Digoxin + Quinapril
Severity: Minor
Digoxin and Quinapril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors have been reported to raise digoxin concentrations modestly in some patients, but the effect is inconsistent. Both drugs are often used together in heart failure, and renal function changes with ACE inhibition may also affect digoxin clearance.
What this interaction means in plain words
Digoxin and Quinapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
The mechanism is not established; changes in renal function from ACE inhibition may reduce digoxin clearance.
What to do
Monitor renal function, potassium and digoxin concentration when starting or adjusting quinapril; reduce the digoxin dose if toxicity signs appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Quinapril?
MediHelp rates the interaction as minor. Digoxin and Quinapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors have been reported to raise digoxin concentrations modestly in some patients, but the effect is inconsistent. Both drugs are often used together in heart failure, and renal function changes with ACE inhibition may also affect digoxin clearance.
How serious is the interaction between Digoxin and Quinapril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, potassium and digoxin concentration when starting or adjusting quinapril; reduce the digoxin dose if toxicity signs appear.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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