Drug interactions
Digoxin + Quinupristin / dalfopristin
Severity: Minor
Digoxin and Quinupristin / dalfopristin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics can eliminate gut bacteria such as Eubacterium lentum that inactivate digoxin, raising digoxin bioavailability in a minority of patients. This can lead to digoxin toxicity. Intravenous quinupristin/dalfopristin has little gut exposure, so the effect is unlikely to be relevant.
What this interaction means in plain words
Digoxin and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction of digoxin-inactivating intestinal flora increases digoxin absorption.
What to do
No routine action is needed; monitor for digoxin toxicity symptoms and check the digoxin level if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Quinupristin / dalfopristin?
MediHelp rates the interaction as minor. Digoxin and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics can eliminate gut bacteria such as Eubacterium lentum that inactivate digoxin, raising digoxin bioavailability in a minority of patients. This can lead to digoxin toxicity. Intravenous quinupristin/dalfopristin has little gut exposure, so the effect is unlikely to be relevant.
How serious is the interaction between Digoxin and Quinupristin / dalfopristin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor for digoxin toxicity symptoms and check the digoxin level if they occur.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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