Drug interactions
Digoxin + Sacubitril / valsartan
Severity: Minor
Digoxin and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sacubitril/valsartan may cause hyperkalemia and renal function changes, and altered potassium affects digoxin toxicity risk. Pharmacokinetic studies showed no meaningful change in digoxin exposure, and the combination is common in heart failure.
What this interaction means in plain words
Digoxin and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic: potassium and renal function shifts from the angiotensin receptor blocker may alter digoxin sensitivity; no significant pharmacokinetic effect.
What to do
Monitor serum potassium, renal function and digoxin concentration periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Digoxin and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sacubitril/valsartan may cause hyperkalemia and renal function changes, and altered potassium affects digoxin toxicity risk. Pharmacokinetic studies showed no meaningful change in digoxin exposure, and the combination is common in heart failure.
How serious is the interaction between Digoxin and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, renal function and digoxin concentration periodically.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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