Drug interactions
Digoxin + Salicylates
Severity: Minor
Digoxin and Salicylates: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates have no established clinically meaningful interaction with digoxin. The legacy potassium rationale is not supported, as digoxin does not raise serum potassium.
What this interaction means in plain words
Digoxin and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; any effect would be via renal function changes.
What to do
No specific action is needed; monitor renal function and digoxin levels if large salicylate doses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Salicylates?
MediHelp rates the interaction as minor. Digoxin and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Non-acetylated salicylates have no established clinically meaningful interaction with digoxin. The legacy potassium rationale is not supported, as digoxin does not raise serum potassium.
How serious is the interaction between Digoxin and Salicylates?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed; monitor renal function and digoxin levels if large salicylate doses are used.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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