Drug interactions
Digoxin + Salsalate
Severity: Minor
Digoxin and Salsalate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a non-acetylated salicylate with no well-documented direct interaction with digoxin. NSAID-like effects on renal function at high doses could theoretically raise digoxin levels.
What this interaction means in plain words
Digoxin and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; possible reduction of renal function and clearance at high doses.
What to do
Monitor renal function and digoxin concentration if salsalate is used long-term at high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Salsalate?
MediHelp rates the interaction as minor. Digoxin and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salsalate is a non-acetylated salicylate with no well-documented direct interaction with digoxin. NSAID-like effects on renal function at high doses could theoretically raise digoxin levels.
How serious is the interaction between Digoxin and Salsalate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and digoxin concentration if salsalate is used long-term at high doses.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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