Drug interactions
Digoxin + Siberian ginseng
Severity: Minor
Digoxin and Siberian ginseng: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siberian ginseng has been associated with a raised measured digoxin concentration in a single case report. The rise appears to have been an analytical artefact, because the herbal product can cross-react with some digoxin immunoassays, and it was not accompanied by clear toxicity. It is therefore of limited clinical significance but can confuse interpretation of levels.
What this interaction means in plain words
Digoxin and Siberian ginseng have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Probable interference with digoxin immunoassay measurement; a true pharmacokinetic effect has not been established.
What to do
If a digoxin level is unexpectedly high in a patient taking this herb, interpret it alongside clinical status and consider a different assay method. Do not adjust the dose on the level alone without signs of toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Siberian ginseng?
MediHelp rates the interaction as minor. Digoxin and Siberian ginseng have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Siberian ginseng has been associated with a raised measured digoxin concentration in a single case report. The rise appears to have been an analytical artefact, because the herbal product can cross-react with some digoxin immunoassays, and it was not accompanied by clear toxicity. It is therefore of limited clinical significance but can confuse interpretation of levels.
How serious is the interaction between Digoxin and Siberian ginseng?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If a digoxin level is unexpectedly high in a patient taking this herb, interpret it alongside clinical status and consider a different assay method. Do not adjust the dose on the level alone without signs of toxicity.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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