Drug interactions
Digoxin + Sodium bicarbonate
Severity: Minor
Digoxin and Sodium bicarbonate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral antacids such as sodium bicarbonate may slightly reduce the absorption of oral digoxin when taken at the same time. The effect is generally small and inconsistent, and it is not expected to cause toxicity.
What this interaction means in plain words
Digoxin and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Sodium bicarbonate belongs to Gastrointestinal Tract.
Why it happens
Possible reduced oral digoxin absorption from altered gastric pH or binding in the gut when given simultaneously.
What to do
Separate oral digoxin from sodium bicarbonate by about 2 hours. Check digoxin levels only if clinical response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Sodium bicarbonate
- Acetylsalicylic acid + Sodium bicarbonate Moderate
- Alendronate + Sodium bicarbonate Moderate
- Amantadine + Sodium bicarbonate Moderate
- Carbonyl iron + Sodium bicarbonate Moderate
- Cefditoren + Sodium bicarbonate Moderate
- Cefpodoxime + Sodium bicarbonate Moderate
Frequently asked questions
Can I take Digoxin with Sodium bicarbonate?
MediHelp rates the interaction as minor. Digoxin and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral antacids such as sodium bicarbonate may slightly reduce the absorption of oral digoxin when taken at the same time. The effect is generally small and inconsistent, and it is not expected to cause toxicity.
How serious is the interaction between Digoxin and Sodium bicarbonate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral digoxin from sodium bicarbonate by about 2 hours. Check digoxin levels only if clinical response changes.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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