Drug interactions
Digoxin + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Digoxin and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This bowel preparation can reduce digoxin absorption through binding to magnesium and rapid GI transit. Diarrhea and electrolyte shifts such as hypokalemia and hypomagnesemia also raise the risk of digoxin toxicity.
What this interaction means in plain words
Digoxin and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation or binding by magnesium and increased GI transit reduce digoxin absorption, while electrolyte loss increases sensitivity.
What to do
Give oral digoxin at least 2 hours before and at least 6 hours after the preparation, and monitor electrolytes and hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Digoxin and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This bowel preparation can reduce digoxin absorption through binding to magnesium and rapid GI transit. Diarrhea and electrolyte shifts such as hypokalemia and hypomagnesemia also raise the risk of digoxin toxicity.
How serious is the interaction between Digoxin and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral digoxin at least 2 hours before and at least 6 hours after the preparation, and monitor electrolytes and hydration.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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