Drug interactions
Digoxin + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Digoxin and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral sulfate bowel preparations cause rapid gut transit, diarrhea and electrolyte shifts, which can reduce digoxin absorption. Fluid and potassium or magnesium disturbances can also increase the risk of digoxin toxicity.
What this interaction means in plain words
Digoxin and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rapid intestinal transit and possible binding reduce digoxin absorption, and electrolyte loss alters sensitivity to digoxin.
What to do
Give digoxin at least 2 hours before the bowel preparation and not within about 6 hours after it. Check potassium and magnesium and monitor digoxin response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Digoxin and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral sulfate bowel preparations cause rapid gut transit, diarrhea and electrolyte shifts, which can reduce digoxin absorption. Fluid and potassium or magnesium disturbances can also increase the risk of digoxin toxicity.
How serious is the interaction between Digoxin and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give digoxin at least 2 hours before the bowel preparation and not within about 6 hours after it. Check potassium and magnesium and monitor digoxin response.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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