Drug interactions
Digoxin + Sulfadiazine
Severity: Minor
Digoxin and Sulfadiazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibacterials that suppress gut flora could theoretically increase digoxin bioavailability in patients who inactivate digoxin by bacteria. No convincing clinical reports exist for sulfadiazine.
What this interaction means in plain words
Digoxin and Sulfadiazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction of digoxin-inactivating gut bacteria.
What to do
No routine action; check digoxin level if signs of toxicity appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Sulfadiazine?
MediHelp rates the interaction as minor. Digoxin and Sulfadiazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibacterials that suppress gut flora could theoretically increase digoxin bioavailability in patients who inactivate digoxin by bacteria. No convincing clinical reports exist for sulfadiazine.
How serious is the interaction between Digoxin and Sulfadiazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action; check digoxin level if signs of toxicity appear.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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