Drug interactions
Digoxin + Sulfamethoxazole
Severity: Minor
Digoxin and Sulfamethoxazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole, usually given with trimethoprim, may raise digoxin concentrations. Trimethoprim can compete for renal tubular secretion, and gut flora changes are theoretical.
What this interaction means in plain words
Digoxin and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Reduced renal tubular secretion of digoxin and possible loss of digoxin-inactivating gut bacteria.
What to do
Monitor digoxin concentration and renal function during co-trimoxazole courses, particularly in older patients or those with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Sulfamethoxazole?
MediHelp rates the interaction as minor. Digoxin and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfamethoxazole, usually given with trimethoprim, may raise digoxin concentrations. Trimethoprim can compete for renal tubular secretion, and gut flora changes are theoretical.
How serious is the interaction between Digoxin and Sulfamethoxazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentration and renal function during co-trimoxazole courses, particularly in older patients or those with renal impairment.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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