Drug interactions
Digoxin + Telmisartan-amlodipine
Severity: Moderate
Digoxin and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan can raise digoxin plasma concentrations, which may increase the risk of digoxin toxicity. Electrolyte shifts from the antihypertensive and renal changes can also alter digoxin sensitivity.
What this interaction means in plain words
Digoxin and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Telmisartan appears to increase digoxin exposure, possibly via P-glycoprotein-mediated effects on absorption or renal elimination.
What to do
Check digoxin levels when telmisartan is started or stopped and monitor potassium and renal function. Reduce the digoxin dose if toxicity signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Digoxin and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telmisartan can raise digoxin plasma concentrations, which may increase the risk of digoxin toxicity. Electrolyte shifts from the antihypertensive and renal changes can also alter digoxin sensitivity.
How serious is the interaction between Digoxin and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check digoxin levels when telmisartan is started or stopped and monitor potassium and renal function. Reduce the digoxin dose if toxicity signs appear.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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