Drug interactions
Digoxin + Telmisartan
Severity: Moderate
Digoxin and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan can raise serum digoxin concentrations modestly, which may increase the chance of digoxin toxicity. Electrolyte shifts, including hyperkalemia from the ARB, can also alter cardiac conduction and digoxin effects.
What this interaction means in plain words
Digoxin and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Telmisartan belongs to Cardiovascular.
Why it happens
Telmisartan likely reduces P-glycoprotein-mediated digoxin elimination, raising digoxin exposure; ARB-related potassium changes add pharmacodynamic effects.
What to do
Measure digoxin concentrations when starting or stopping telmisartan and adjust the digoxin dose as needed. Monitor potassium, renal function and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Telmisartan?
MediHelp rates the interaction as moderate. Digoxin and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telmisartan can raise serum digoxin concentrations modestly, which may increase the chance of digoxin toxicity. Electrolyte shifts, including hyperkalemia from the ARB, can also alter cardiac conduction and digoxin effects.
How serious is the interaction between Digoxin and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure digoxin concentrations when starting or stopping telmisartan and adjust the digoxin dose as needed. Monitor potassium, renal function and ECG.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
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