Drug interactions
Digoxin + Tenofovir disoproxil
Severity: Minor
Digoxin and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir may reduce renal elimination of digoxin through competition at tubular transporters such as P-glycoprotein. Clinical data show little effect on digoxin exposure, so any increase is likely small.
What this interaction means in plain words
Digoxin and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion including P-glycoprotein.
What to do
No empirical dose change is needed. Monitor digoxin concentrations and clinical signs of toxicity, especially with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Digoxin and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tenofovir may reduce renal elimination of digoxin through competition at tubular transporters such as P-glycoprotein. Clinical data show little effect on digoxin exposure, so any increase is likely small.
How serious is the interaction between Digoxin and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor digoxin concentrations and clinical signs of toxicity, especially with renal impairment.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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