Drug interactions
Digoxin + Teriparatide
Severity: Moderate
Digoxin and Teriparatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriparatide can cause transient rises in serum calcium after dosing. Hypercalcemia increases myocardial sensitivity to digoxin, so toxicity could theoretically occur, although reports are rare.
What this interaction means in plain words
Digoxin and Teriparatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Teriparatide belongs to Musculoskeletal.
Why it happens
Transient teriparatide-induced hypercalcemia sensitizes the myocardium to digitalis glycosides, increasing arrhythmia risk.
What to do
Monitor serum calcium and digoxin levels, and watch for signs of digoxin toxicity such as nausea, visual changes and arrhythmias. Adjust the digoxin dose if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriparatide
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Teriparatide?
MediHelp rates the interaction as moderate. Digoxin and Teriparatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teriparatide can cause transient rises in serum calcium after dosing. Hypercalcemia increases myocardial sensitivity to digoxin, so toxicity could theoretically occur, although reports are rare.
How serious is the interaction between Digoxin and Teriparatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and digoxin levels, and watch for signs of digoxin toxicity such as nausea, visual changes and arrhythmias. Adjust the digoxin dose if toxicity is suspected.
What other medicines interact with Teriparatide?
MediHelp also lists interactions of Teriparatide with, for example, Alendronate, Calcium acetate, Calcium carbonate. The full list is on the Teriparatide page.
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