Drug interactions
Digoxin + Thalidomide
Severity: Moderate
Digoxin and Thalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thalidomide can cause bradycardia, and digoxin slows atrioventricular conduction. Taken together they may produce additive slowing of heart rate or conduction block, with symptoms such as dizziness, syncope or hypotension.
What this interaction means in plain words
Digoxin and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Thalidomide belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic slowing of heart rate and AV nodal conduction.
What to do
Monitor heart rate and ECG when starting or adjusting either drug, especially in older patients or those with conduction disease. Reduce or stop one agent if symptomatic bradycardia or AV block develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thalidomide
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Thalidomide?
MediHelp rates the interaction as moderate. Digoxin and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thalidomide can cause bradycardia, and digoxin slows atrioventricular conduction. Taken together they may produce additive slowing of heart rate or conduction block, with symptoms such as dizziness, syncope or hypotension.
How serious is the interaction between Digoxin and Thalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG when starting or adjusting either drug, especially in older patients or those with conduction disease. Reduce or stop one agent if symptomatic bradycardia or AV block develops.
What other medicines interact with Thalidomide?
MediHelp also lists interactions of Thalidomide with, for example, Bortezomib, Carbamazepine, Griseofulvin. The full list is on the Thalidomide page.
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