Drug interactions
Digoxin + Thyroid desiccated
Severity: Moderate
Digoxin and Thyroid desiccated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Correcting hypothyroidism increases digoxin clearance and volume of distribution, so digoxin effect and concentrations may fall after thyroid replacement is started. Conversely, reducing thyroid dose may raise digoxin levels.
What this interaction means in plain words
Digoxin and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thyroid hormone increases metabolic rate, renal clearance and distribution of digoxin.
What to do
Monitor digoxin concentration and clinical response when thyroid replacement is started or changed, and adjust the digoxin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Thyroid desiccated?
MediHelp rates the interaction as moderate. Digoxin and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Correcting hypothyroidism increases digoxin clearance and volume of distribution, so digoxin effect and concentrations may fall after thyroid replacement is started. Conversely, reducing thyroid dose may raise digoxin levels.
How serious is the interaction between Digoxin and Thyroid desiccated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentration and clinical response when thyroid replacement is started or changed, and adjust the digoxin dose.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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