Drug interactions
Digoxin + Trimagnesium
Severity: Minor
Digoxin and Trimagnesium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral magnesium salts may bind digoxin in the gut and reduce absorption, and magnesium status affects digoxin toxicity risk. The legacy claim that digoxin increases magnesium clearance is not an established clinical interaction.
What this interaction means in plain words
Digoxin and Trimagnesium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Adsorption or binding of digoxin by magnesium salts in the GI tract may reduce absorption.
What to do
Separate oral digoxin from magnesium products by about 2 hours and monitor digoxin concentration and serum magnesium.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Trimagnesium?
MediHelp rates the interaction as minor. Digoxin and Trimagnesium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral magnesium salts may bind digoxin in the gut and reduce absorption, and magnesium status affects digoxin toxicity risk. The legacy claim that digoxin increases magnesium clearance is not an established clinical interaction.
How serious is the interaction between Digoxin and Trimagnesium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral digoxin from magnesium products by about 2 hours and monitor digoxin concentration and serum magnesium.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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