Drug interactions
Digoxin + Trospium chloride
Severity: Moderate
Digoxin and Trospium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are eliminated partly by active renal tubular secretion, so co-administration may raise exposure to either one. This could increase digoxin toxicity or anticholinergic adverse effects of trospium, particularly in patients with reduced renal function.
What this interaction means in plain words
Digoxin and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion, possibly via P-glycoprotein and cationic transporters, may reduce renal clearance of both drugs.
What to do
Monitor digoxin concentrations and clinical signs of toxicity, and watch for anticholinergic effects of trospium. Adjust the digoxin dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Trospium chloride?
MediHelp rates the interaction as moderate. Digoxin and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are eliminated partly by active renal tubular secretion, so co-administration may raise exposure to either one. This could increase digoxin toxicity or anticholinergic adverse effects of trospium, particularly in patients with reduced renal function.
How serious is the interaction between Digoxin and Trospium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentrations and clinical signs of toxicity, and watch for anticholinergic effects of trospium. Adjust the digoxin dose if levels rise.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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