Drug interactions
Digoxin + Ulipristal
Severity: Moderate
Digoxin and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ulipristal may increase digoxin concentrations through P-glycoprotein inhibition. The effect is likely most relevant after a single emergency dose, but digoxin toxicity is possible in susceptible patients.
What this interaction means in plain words
Digoxin and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ulipristal inhibits P-glycoprotein, reducing digoxin efflux and clearance.
What to do
Monitor for signs of digoxin toxicity and check serum digoxin level if symptoms occur. Consider a digoxin dose reduction if repeated exposure is expected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Ulipristal?
MediHelp rates the interaction as moderate. Digoxin and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ulipristal may increase digoxin concentrations through P-glycoprotein inhibition. The effect is likely most relevant after a single emergency dose, but digoxin toxicity is possible in susceptible patients.
How serious is the interaction between Digoxin and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of digoxin toxicity and check serum digoxin level if symptoms occur. Consider a digoxin dose reduction if repeated exposure is expected.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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