Drug interactions
Digoxin + Vibegron
Severity: Moderate
Digoxin and Vibegron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vibegron increases digoxin peak and total exposure, which may raise the risk of digoxin toxicity such as arrhythmia, nausea and visual disturbance. This matters because digoxin has a narrow therapeutic range.
What this interaction means in plain words
Digoxin and Vibegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Vibegron belongs to Genitourinary.
Why it happens
Vibegron probably inhibits intestinal P-glycoprotein, increasing digoxin absorption.
What to do
Measure serum digoxin before starting vibegron and during therapy, and adjust the digoxin dose. Continue monitoring after vibegron is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Vibegron?
MediHelp rates the interaction as moderate. Digoxin and Vibegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vibegron increases digoxin peak and total exposure, which may raise the risk of digoxin toxicity such as arrhythmia, nausea and visual disturbance. This matters because digoxin has a narrow therapeutic range.
How serious is the interaction between Digoxin and Vibegron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum digoxin before starting vibegron and during therapy, and adjust the digoxin dose. Continue monitoring after vibegron is stopped.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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