Drug interactions
Digoxin + Vincristine liposomal
Severity: Minor
Digoxin and Vincristine liposomal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vincristine is reported to reduce oral digoxin absorption, possibly lowering digoxin levels and efficacy. This is associated mainly with combination cytotoxic regimens damaging the intestinal mucosa, and the liposomal formulation is not an established cause.
What this interaction means in plain words
Digoxin and Vincristine liposomal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cytotoxic injury to the intestinal mucosa may impair absorption of oral digoxin; the effect with liposomal vincristine is not well established.
What to do
Monitor heart rate, symptoms and serum digoxin levels during chemotherapy. Consider digoxin solution or capsules, or an intravenous route, if levels are low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Vincristine liposomal?
MediHelp rates the interaction as minor. Digoxin and Vincristine liposomal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vincristine is reported to reduce oral digoxin absorption, possibly lowering digoxin levels and efficacy. This is associated mainly with combination cytotoxic regimens damaging the intestinal mucosa, and the liposomal formulation is not an established cause.
How serious is the interaction between Digoxin and Vincristine liposomal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, symptoms and serum digoxin levels during chemotherapy. Consider digoxin solution or capsules, or an intravenous route, if levels are low.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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