Drug interactions
Digoxin + Zanubrutinib
Severity: Moderate
Digoxin and Zanubrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zanubrutinib may increase digoxin concentrations, raising the risk of digoxin toxicity such as arrhythmias, nausea and visual disturbance. Zanubrutinib itself is associated with atrial fibrillation, which complicates cardiac management.
What this interaction means in plain words
Digoxin and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Zanubrutinib belongs to Oncology.
Why it happens
Zanubrutinib may inhibit intestinal P-glycoprotein, increasing digoxin absorption.
What to do
Monitor serum digoxin levels and ECG; consider separating doses by at least 2 hours and reduce digoxin if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zanubrutinib
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Zanubrutinib?
MediHelp rates the interaction as moderate. Digoxin and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zanubrutinib may increase digoxin concentrations, raising the risk of digoxin toxicity such as arrhythmias, nausea and visual disturbance. Zanubrutinib itself is associated with atrial fibrillation, which complicates cardiac management.
How serious is the interaction between Digoxin and Zanubrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin levels and ECG; consider separating doses by at least 2 hours and reduce digoxin if needed.
What other medicines interact with Zanubrutinib?
MediHelp also lists interactions of Zanubrutinib with, for example, Alteplase, Amobarbital, Apalutamide. The full list is on the Zanubrutinib page.
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