Drug interactions
Dihydroergotamine + Griseofulvin
Severity: Minor
Dihydroergotamine and Griseofulvin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may lower dihydroergotamine levels, which would reduce its efficacy rather than cause ergot toxicity. The clinical significance is limited and the interaction is theoretical.
What this interaction means in plain words
Dihydroergotamine and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dihydroergotamine belongs to Central Nervous System; Griseofulvin belongs to Anti Fungals.
Why it happens
Griseofulvin is a weak CYP3A4 inducer that may modestly increase dihydroergotamine metabolism.
What to do
No routine action is needed. Watch for reduced migraine response and adjust therapy if efficacy declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Griseofulvin?
MediHelp rates the interaction as minor. Dihydroergotamine and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin may lower dihydroergotamine levels, which would reduce its efficacy rather than cause ergot toxicity. The clinical significance is limited and the interaction is theoretical.
How serious is the interaction between Dihydroergotamine and Griseofulvin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Watch for reduced migraine response and adjust therapy if efficacy declines.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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