Drug interactions
Dihydroergotamine + Xylometazoline
Severity: Moderate
Dihydroergotamine and Xylometazoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xylometazoline is a nasal decongestant vasoconstrictor with low systemic absorption. Additive vasoconstriction with dihydroergotamine is possible but clinically modest at normal topical doses.
What this interaction means in plain words
Dihydroergotamine and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Xylometazoline belongs to Respiratory.
Why it happens
Additive vasoconstriction from alpha-adrenergic agonism and ergot vascular effects.
What to do
Limit xylometazoline to short courses at label doses and monitor blood pressure. Stop it if headache, chest pain or limb ischemia symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dihydroergotamine and Xylometazoline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Xylometazoline
- Selegiline + Xylometazoline Contraindicated
- Ergotamine + Xylometazoline Major
- Isocarboxazid + Xylometazoline Major
- Phenelzine + Xylometazoline Major
- Tranylcypromine + Xylometazoline Major
- Amitriptyline + Xylometazoline Moderate
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Xylometazoline?
MediHelp rates the interaction as moderate. Dihydroergotamine and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xylometazoline is a nasal decongestant vasoconstrictor with low systemic absorption. Additive vasoconstriction with dihydroergotamine is possible but clinically modest at normal topical doses.
How serious is the interaction between Dihydroergotamine and Xylometazoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit xylometazoline to short courses at label doses and monitor blood pressure. Stop it if headache, chest pain or limb ischemia symptoms occur.
What other medicines interact with Xylometazoline?
MediHelp also lists interactions of Xylometazoline with, for example, Selegiline, Ergotamine, Isocarboxazid. The full list is on the Xylometazoline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
