Drug interactions
Dihydroergotamine intranasal + Eletriptan
Severity: Contraindicated
Dihydroergotamine intranasal and Eletriptan: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic absorption of intranasal dihydroergotamine adds to the vasoconstrictor effect of eletriptan, risking prolonged vasospasm and ischemia.
What this interaction means in plain words
Dihydroergotamine intranasal and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive vasoconstriction via 5-HT1B/1D agonism and ergot vascular receptor effects.
What to do
Do not combine; leave at least 24 hours between doses. Use a single acute therapy per attack.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine intranasal with Eletriptan?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Systemic absorption of intranasal dihydroergotamine adds to the vasoconstrictor effect of eletriptan, risking prolonged vasospasm and ischemia.
How serious is the interaction between Dihydroergotamine intranasal and Eletriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; leave at least 24 hours between doses. Use a single acute therapy per attack.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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