Drug interactions
Dihydroergotamine intranasal + Sotalol
Severity: Moderate
Dihydroergotamine intranasal and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine causes vasoconstriction, and beta-blockers may blunt beta-2-mediated vasodilation, so peripheral ischemia or vasospasm could be potentiated. Intranasal dosing gives lower but still systemically relevant exposure.
What this interaction means in plain words
Dihydroergotamine intranasal and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ergot alpha-adrenergic vasoconstriction is unopposed when beta-2 vasodilation is blocked.
What to do
Monitor for cold extremities, paresthesias, or chest pain. Stop the ergot and seek review if ischemic symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dihydroergotamine intranasal and Sotalol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Dihydroergotamine intranasal with Sotalol?
MediHelp rates the interaction as moderate. Dihydroergotamine intranasal and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine causes vasoconstriction, and beta-blockers may blunt beta-2-mediated vasodilation, so peripheral ischemia or vasospasm could be potentiated. Intranasal dosing gives lower but still systemically relevant exposure.
How serious is the interaction between Dihydroergotamine intranasal and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cold extremities, paresthesias, or chest pain. Stop the ergot and seek review if ischemic symptoms develop.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
