Drug interactions
Diltiazem + Fedratinib
Severity: Moderate
Diltiazem and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and may increase diltiazem concentrations. This can cause excess bradycardia, AV block or hypotension.
What this interaction means in plain words
Diltiazem and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4-mediated metabolism of diltiazem.
What to do
Monitor heart rate, ECG and blood pressure, and reduce the diltiazem dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Diltiazem with Fedratinib?
MediHelp rates the interaction as moderate. Diltiazem and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and may increase diltiazem concentrations. This can cause excess bradycardia, AV block or hypotension.
How serious is the interaction between Diltiazem and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and blood pressure, and reduce the diltiazem dose if bradycardia or hypotension develops.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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