Drug interactions
Diltiazem + Fostamatinib
Severity: Minor
Diltiazem and Fostamatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite inhibits P-glycoprotein and may modestly increase diltiazem exposure. This could enhance diltiazem effects such as bradycardia or hypotension.
What this interaction means in plain words
Diltiazem and Fostamatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diltiazem belongs to Cardiovascular; Fostamatinib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux by the fostamatinib metabolite increases diltiazem absorption.
What to do
Monitor heart rate and blood pressure, and reduce the diltiazem dose if excessive effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Diltiazem with Fostamatinib?
MediHelp rates the interaction as minor. Diltiazem and Fostamatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostamatinib's active metabolite inhibits P-glycoprotein and may modestly increase diltiazem exposure. This could enhance diltiazem effects such as bradycardia or hypotension.
How serious is the interaction between Diltiazem and Fostamatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and reduce the diltiazem dose if excessive effects appear.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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