Drug interactions
Diltiazem + Levamlodipine
Severity: Moderate
Diltiazem and Levamlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem increases levamlodipine exposure, which may cause hypotension, peripheral edema and reflex tachycardia or dizziness.
What this interaction means in plain words
Diltiazem and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Levamlodipine belongs to Cardiovascular.
Why it happens
Diltiazem inhibits CYP3A4 metabolism of levamlodipine, with additive vasodilation.
What to do
Monitor blood pressure and edema, and reduce the levamlodipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Diltiazem with Levamlodipine?
MediHelp rates the interaction as moderate. Diltiazem and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem increases levamlodipine exposure, which may cause hypotension, peripheral edema and reflex tachycardia or dizziness.
How serious is the interaction between Diltiazem and Levamlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and reduce the levamlodipine dose if hypotension or edema develops.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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