Drug interactions
Apalutamide + Levamlodipine
Severity: Moderate
Apalutamide and Levamlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levamlodipine, the active enantiomer of amlodipine, is metabolized by CYP3A4, which apalutamide induces. Blood pressure control may be reduced.
What this interaction means in plain words
Apalutamide and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Levamlodipine belongs to Cardiovascular.
Why it happens
Apalutamide induces CYP3A4, increasing the clearance of levamlodipine.
What to do
Monitor blood pressure after apalutamide is started or stopped. Increase the levamlodipine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
- Carbamazepine + Levamlodipine Moderate
Frequently asked questions
Can I take Apalutamide with Levamlodipine?
MediHelp rates the interaction as moderate. Apalutamide and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levamlodipine, the active enantiomer of amlodipine, is metabolized by CYP3A4, which apalutamide induces. Blood pressure control may be reduced.
How serious is the interaction between Apalutamide and Levamlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after apalutamide is started or stopped. Increase the levamlodipine dose if needed.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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