Drug interactions
Armodafinil + Levamlodipine
Severity: Moderate
Armodafinil and Levamlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levamlodipine is metabolized by CYP3A4, so armodafinil's weak induction may reduce its blood pressure lowering effect. Armodafinil itself can also raise blood pressure.
What this interaction means in plain words
Armodafinil and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Levamlodipine belongs to Cardiovascular.
Why it happens
CYP3A4 induction by armodafinil increases levamlodipine clearance, with opposing pressor effects.
What to do
Monitor blood pressure after starting or stopping armodafinil and increase the levamlodipine dose if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Carbamazepine + Levamlodipine Moderate
Frequently asked questions
Can I take Armodafinil with Levamlodipine?
MediHelp rates the interaction as moderate. Armodafinil and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levamlodipine is metabolized by CYP3A4, so armodafinil's weak induction may reduce its blood pressure lowering effect. Armodafinil itself can also raise blood pressure.
How serious is the interaction between Armodafinil and Levamlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping armodafinil and increase the levamlodipine dose if control is lost.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Cyclosporine, Elacestrant. The full list is on the Armodafinil page.
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