Drug interactions
Amiodarone + Levamlodipine
Severity: Moderate
Amiodarone and Levamlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may increase levamlodipine exposure, and both can cause hypotension and bradycardia. Edema and low blood pressure may become more pronounced.
What this interaction means in plain words
Amiodarone and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Levamlodipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 metabolism of levamlodipine by amiodarone plus additive hemodynamic effects.
What to do
Monitor blood pressure, heart rate and peripheral edema, and reduce the levamlodipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
- Carbamazepine + Levamlodipine Moderate
Frequently asked questions
Can I take Amiodarone with Levamlodipine?
MediHelp rates the interaction as moderate. Amiodarone and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may increase levamlodipine exposure, and both can cause hypotension and bradycardia. Edema and low blood pressure may become more pronounced.
How serious is the interaction between Amiodarone and Levamlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and peripheral edema, and reduce the levamlodipine dose if hypotension or edema develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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