Drug interactions
Aprepitant + Levamlodipine
Severity: Moderate
Aprepitant and Levamlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant may increase levamlodipine exposure through CYP3A4 inhibition. This may cause hypotension and peripheral edema.
What this interaction means in plain words
Aprepitant and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Levamlodipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated metabolism of levamlodipine by aprepitant.
What to do
Monitor blood pressure and for edema, and reduce the levamlodipine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
- Carbamazepine + Levamlodipine Moderate
Frequently asked questions
Can I take Aprepitant with Levamlodipine?
MediHelp rates the interaction as moderate. Aprepitant and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant may increase levamlodipine exposure through CYP3A4 inhibition. This may cause hypotension and peripheral edema.
How serious is the interaction between Aprepitant and Levamlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema, and reduce the levamlodipine dose if needed.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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