Drug interactions
Diltiazem + Methamphetamine
Severity: Moderate
Diltiazem and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine raises blood pressure and heart rate and can counteract the antihypertensive and rate-controlling effect of diltiazem. Stimulant-related tachyarrhythmia and hypertension may be harder to control.
What this interaction means in plain words
Diltiazem and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Methamphetamine belongs to Central Nervous System.
Why it happens
Sympathomimetic pressor activity opposes calcium channel blockade.
What to do
Monitor blood pressure and heart rate and adjust antihypertensive therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Diltiazem with Methamphetamine?
MediHelp rates the interaction as moderate. Diltiazem and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methamphetamine raises blood pressure and heart rate and can counteract the antihypertensive and rate-controlling effect of diltiazem. Stimulant-related tachyarrhythmia and hypertension may be harder to control.
How serious is the interaction between Diltiazem and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and adjust antihypertensive therapy as needed.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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