Drug interactions
Diltiazem + Midostaurin
Severity: Moderate
Diltiazem and Midostaurin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may increase midostaurin concentrations and its adverse effects, including nausea, infection risk and QT effects.
What this interaction means in plain words
Diltiazem and Midostaurin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Midostaurin belongs to Oncology.
Why it happens
Diltiazem inhibits CYP3A4, which metabolizes midostaurin.
What to do
Monitor for midostaurin toxicity, particularly in the first week of therapy. Consider an alternative to diltiazem.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Midostaurin
Frequently asked questions
Can I take Diltiazem with Midostaurin?
MediHelp rates the interaction as moderate. Diltiazem and Midostaurin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may increase midostaurin concentrations and its adverse effects, including nausea, infection risk and QT effects.
How serious is the interaction between Diltiazem and Midostaurin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for midostaurin toxicity, particularly in the first week of therapy. Consider an alternative to diltiazem.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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