Drug interactions
Diltiazem + Omaveloxolone
Severity: Moderate
Diltiazem and Omaveloxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may raise omaveloxolone levels because omaveloxolone is a CYP3A4 substrate. Higher exposure can increase adverse effects such as liver enzyme elevation, headache and nausea.
What this interaction means in plain words
Diltiazem and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Omaveloxolone belongs to Central Nervous System.
Why it happens
Diltiazem inhibits CYP3A4, reducing omaveloxolone clearance.
What to do
Avoid the combination if possible. If it is necessary, lower the omaveloxolone dose per labeling and monitor liver enzymes, lipids and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Diltiazem with Omaveloxolone?
MediHelp rates the interaction as moderate. Diltiazem and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may raise omaveloxolone levels because omaveloxolone is a CYP3A4 substrate. Higher exposure can increase adverse effects such as liver enzyme elevation, headache and nausea.
How serious is the interaction between Diltiazem and Omaveloxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it is necessary, lower the omaveloxolone dose per labeling and monitor liver enzymes, lipids and tolerability.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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