Drug interactions
Apalutamide + Omaveloxolone
Severity: Major
Apalutamide and Omaveloxolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may decrease omaveloxolone exposure, which is metabolized mainly by CYP3A4, reducing its therapeutic effect in Friedreich ataxia.
What this interaction means in plain words
Apalutamide and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Omaveloxolone belongs to Central Nervous System.
Why it happens
Apalutamide induces CYP3A4, increasing omaveloxolone clearance.
What to do
Avoid concomitant use with strong or moderate CYP3A4 inducers. Monitor clinical response if coadministration is unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Apalutamide with Omaveloxolone?
MediHelp rates the interaction as major. Apalutamide and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may decrease omaveloxolone exposure, which is metabolized mainly by CYP3A4, reducing its therapeutic effect in Friedreich ataxia.
How serious is the interaction between Apalutamide and Omaveloxolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use with strong or moderate CYP3A4 inducers. Monitor clinical response if coadministration is unavoidable.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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