Drug interactions
Chloramphenicol + Omaveloxolone
Severity: Major
Chloramphenicol and Omaveloxolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol can inhibit CYP3A4, the main enzyme clearing omaveloxolone, and may raise omaveloxolone exposure. Higher levels may increase adverse effects such as liver enzyme elevation and other dose-related toxicity.
What this interaction means in plain words
Chloramphenicol and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Omaveloxolone belongs to Central Nervous System.
Why it happens
Chloramphenicol inhibits CYP3A4-mediated metabolism of omaveloxolone, reducing its clearance.
What to do
Prefer an alternative antibiotic. If unavoidable, reduce the omaveloxolone dose per labeling for CYP3A4 inhibitors and monitor liver tests and tolerability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Chloramphenicol with Omaveloxolone?
MediHelp rates the interaction as major. Chloramphenicol and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloramphenicol can inhibit CYP3A4, the main enzyme clearing omaveloxolone, and may raise omaveloxolone exposure. Higher levels may increase adverse effects such as liver enzyme elevation and other dose-related toxicity.
How serious is the interaction between Chloramphenicol and Omaveloxolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic. If unavoidable, reduce the omaveloxolone dose per labeling for CYP3A4 inhibitors and monitor liver tests and tolerability.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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