Drug interactions
Clarithromycin + Omaveloxolone
Severity: Major
Clarithromycin and Omaveloxolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may substantially increase omaveloxolone exposure, raising the risk of liver enzyme elevation and other adverse effects.
What this interaction means in plain words
Clarithromycin and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Omaveloxolone belongs to Central Nervous System.
Why it happens
Strong CYP3A4 inhibition reduces omaveloxolone metabolism.
What to do
Avoid the combination when possible. If unavoidable, reduce the omaveloxolone dose per labeling and monitor liver tests.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Clarithromycin with Omaveloxolone?
MediHelp rates the interaction as major. Clarithromycin and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin may substantially increase omaveloxolone exposure, raising the risk of liver enzyme elevation and other adverse effects.
How serious is the interaction between Clarithromycin and Omaveloxolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible. If unavoidable, reduce the omaveloxolone dose per labeling and monitor liver tests.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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