Drug interactions
Aprepitant + Omaveloxolone
Severity: Major
Aprepitant and Omaveloxolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone is metabolized largely by CYP3A4, and aprepitant can increase its exposure. This may lead to more adverse effects such as liver enzyme elevation, nausea and fatigue.
What this interaction means in plain words
Aprepitant and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Omaveloxolone belongs to Central Nervous System.
Why it happens
Aprepitant, a moderate CYP3A4 inhibitor, reduces omaveloxolone clearance.
What to do
Avoid if possible; if unavoidable, reduce the omaveloxolone dose per labeling and monitor for adverse effects and liver enzymes. Restore the usual dose after the inhibitor is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aprepitant and Omaveloxolone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Aprepitant with Omaveloxolone?
MediHelp rates the interaction as major. Aprepitant and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Omaveloxolone is metabolized largely by CYP3A4, and aprepitant can increase its exposure. This may lead to more adverse effects such as liver enzyme elevation, nausea and fatigue.
How serious is the interaction between Aprepitant and Omaveloxolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if unavoidable, reduce the omaveloxolone dose per labeling and monitor for adverse effects and liver enzymes. Restore the usual dose after the inhibitor is stopped.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
