Drug interactions
Diltiazem + Palbociclib
Severity: Moderate
Diltiazem and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem, a moderate CYP3A4 inhibitor, may raise palbociclib exposure and increase neutropenia and other adverse effects.
What this interaction means in plain words
Diltiazem and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Palbociclib belongs to Oncology.
Why it happens
Diltiazem inhibits CYP3A4, the main pathway for palbociclib metabolism.
What to do
Monitor complete blood counts closely and reduce the palbociclib dose if neutropenia occurs. Consider an alternative to diltiazem.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Palbociclib
Frequently asked questions
Can I take Diltiazem with Palbociclib?
MediHelp rates the interaction as moderate. Diltiazem and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem, a moderate CYP3A4 inhibitor, may raise palbociclib exposure and increase neutropenia and other adverse effects.
How serious is the interaction between Diltiazem and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and reduce the palbociclib dose if neutropenia occurs. Consider an alternative to diltiazem.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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