Drug interactions
Diltiazem + Temsirolimus
Severity: Moderate
Diltiazem and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may increase exposure to temsirolimus and its active metabolite sirolimus. Calcium channel blockers with mTOR inhibitors have also been associated with a higher risk of angioedema.
What this interaction means in plain words
Diltiazem and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
Diltiazem inhibits CYP3A4, reducing temsirolimus metabolism; the angioedema mechanism is not well established.
What to do
Monitor for mTOR inhibitor toxicity such as mucositis, cytopenias, hyperglycemia and angioedema, and reduce the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Diltiazem with Temsirolimus?
MediHelp rates the interaction as moderate. Diltiazem and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may increase exposure to temsirolimus and its active metabolite sirolimus. Calcium channel blockers with mTOR inhibitors have also been associated with a higher risk of angioedema.
How serious is the interaction between Diltiazem and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mTOR inhibitor toxicity such as mucositis, cytopenias, hyperglycemia and angioedema, and reduce the dose if needed.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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